职称/职务：副研究员

电子信箱：qiaoyn@snnu.edu.cn

研究方向：神经生物学

一、 教育与工作经历

1. 主要学习经历

2003/09-2007/06：西北大学，生命科学学院生命科学与技术基地班，

                 获理学学士学位；

2007/09-2013/06：南京大学模式动物研究所，硕博连读，生物学博士。

2. 主要工作经历

2013/09-2017/01：伟德源自英国始于1946，现代教学技术教育部重点实验室，

                 生物学站，师资博士后。

2017/01-至今，伟德源自英国始于1946，现代教学技术教育部重点实验室，教师。

二、承担的科研项目

1. 陕西省自然科学基础研究计划项目面上项目，2023.01.01 -2024.12.31, 项目编号： 2023-JC-YB-189

2. 国家自然科学基金青年项目，2016.01.01-2018.12.31，项目编号：31501864；

3. 陕西省自然科学基础研究计划项目青年项目，2016.01.01- 2017.12.31，项目编号：2016JQ3001；

4. 国家博士后基金项目一等资助，2014.01.01- 2015.12.31项目编号：2014M560746；

5. 中央高校项目2项。

三、代表性论文

1. Zhang J, Yu K, Zhang J, Chang Y, Sun X, Qian Z, Sun Z, Qiao Y, Liu Z, Ren W, Han J*: A stress-activated neuronal ensemble in the supramammillary nucleus produces anxiety-like behavior in male mice. eLife 2026, 14.

2. Zhang J, Han W, Chang Y, Xu F, Zheng Q, Wei C, Qiao Y, Liu Z, Han J*, Zhang J*: Memory consolidation deficits arise from CB1R-mediated structural-functional decoupling in inhibitory circuits. Neurobiology of disease 2026, 221:107335.

3. Jiang Y, Tao M, Zhang C, Wu J, Xie J, He X, Fan N, Qu W, Wang C, Zhang J, Liu Z, Ren W, Han J, Qiao Y*: Glutamatergic cannabinoid receptor 1 confers neuroprotection against ischemic stroke by suppressing excitotoxicity and anoxic depolarization. Neuropharmacology 2026, 291:110926.

4. Du Y, Zhang A, Li Z, Zhao Y, Liu S, Wei C, Zheng Q, Qiao Y, Liu Y, Ren W, Han J, Liu Z, Gao F*: Role of astrocytic mu-opioid receptors of the ventrolateral periaqueductal gray in modulating anxiety-like responses. Behavioral and brain functions : BBF 2025, 21(1):24.

5. Xu FH, Sun X, Zhu J, Kong LY, Chang Y, Li N, Hui WX, Zhang CP, Cheng YM, Han WX, Tian ZM, Qiao YN, Chen DF, Liu L, Feng DY, Han *J: Significance of the gut tract in the therapeutic mechanisms of polydopamine for acute cerebral infarction: neuro-immune interaction through the gut-brain axis. Frontiers in cellular and infection microbiology 2024, 14:1413018.

6. Du Y, Zhao Y, Zhang A, Li Z, Wei C, Zheng Q, Qiao Y, Liu Y, Ren W, Han J, Sun Z, Hu W, Liu Z*: The Role of the Mu Opioid Receptors of the Medial Prefrontal Cortex in the Modulation of Analgesia Induced by Acute Restraint Stress in Male Mice. Int J Mol Sci 2024, 25(18).

7. Wang LN, Xing MD, Qu WT, Wang CB, Liu ZQ, Han J, Ren W, Qiao YN*: Impaired vessel relaxation response and increased infarct size in smooth muscle cannabinoid receptor 1 knockout mice. Microvascular research 2022, 139:104263.

8. Du Y, Yu K, Yan C, Wei C, Zheng Q, Qiao Y, Liu Y, Han J, Ren W, Liu Z*: The Contributions of Mu-Opioid Receptors on Glutamatergic and GABAergic Neurons to Analgesia Induced by Various Stress Intensities. eNeuro 2022, 9(3).

9. Sun J^#, Qiao YN^#(Co-first), Tao T, Zhao W, Wei LS, Li YQ, Wang W, Wang Y, Zhou YW, Zheng YY, Chen X, Pan HC, Zhang XN, Zhu MS*: Distinct Roles of Smooth Muscle and Non-muscle Myosin Light Chain-Mediated Smooth Muscle Contraction. Front Physiol 2020, 11:593966.

10. Shi MM^#, Fan KM^#, Qiao YN^#(Co-first), Xu JH, Qiu LJ, Li X, Liu Y, Qian ZQ, Wei CL, Han J, Fan J, Tian YF, Ren W, Liu ZQ*: Hippocampal µ-opioid receptors on GABAergic neurons mediate stress-induced impairment of memory retrieval. Molecular psychiatry 2020, 25(5):977-992.

11. Liu S, Jiang X, Lu H, Xing M, Qiao Y, Zhang C, Zhang W*: HuR (Human Antigen R) Regulates the Contraction of Vascular Smooth Muscle and Maintains Blood Pressure. Arterioscler Thromb Vasc Biol 2020, 40(4):943-957.

12. Yao L, Li Y, Qian Z, Wu M, Yang H, Chen N, Qiao Y, Wei C, Zheng Q, Han J, Tian Y, Liu Z, Ren W*: Loss of control over mild aversive events produces significant helplessness in mice. Behav Brain Res 2019, 376:112173.

13. Sun J, Tao T, Zhao W, Wei L, She F, Wang P, Li Y, Zheng Y, Chen X, Wang W, Qiao Y, Zhang XN, Zhu MS*: CPI-17-mediated contraction of vascular smooth muscle is essential for the development of hypertension in obese mice. Journal of genetics and genomics 2019, 46(3):109-118.

14. Qian Z, Wu X, Qiao Y, Shi M, Liu Z, Ren W, Han J, Zheng Q*: Downregulation of mGluR2/3 receptors during morphine withdrawal in rats impairs mGluR2/3- and NMDA receptor-dependent long-term depression in the nucleus accumbens. Neuroscience letters 2019, 690:76-82.

15. Zhang R, Zhou J, Ren J, Sun S, Di Y, Wang H, An X, Zhang K, Zhang J, Qian Z, Shi M, Qiao Y, Ren W, Tian Y*: Transcriptional and splicing dysregulation in the prefrontal cortex in valproic acid rat model of autism. Reproductive toxicology (Elmsford, NY) 2018, 77:53-61.

16. Zhang CH, Wang P, Liu DH, Chen CP, Zhao W, Chen X, Chen C, He WQ, Qiao YN, Tao T, Sun J, Peng YJ, Lu P, Zheng K, Craige SM, Lifshitz LM, Keaney JF, Jr., Fogarty KE, ZhuGe R, Zhu MS*: The molecular basis of the genesis of basal tone in internal anal sphincter. Nat Commun 2016, 7:11358.

17. Gao N, Chang AN, He W, Chen CP, Qiao YN, Zhu M, Kamm KE, Stull JT: Physiological signalling to myosin phosphatase targeting subunit-1 phosphorylation in ileal smooth muscle. J Physiol 2016, 594(12):3209-3225.

18. Chen CP, Chen X, Qiao YN, Wang P, He WQ, Zhang CH, Zhao W, Gao YQ, Chen C, Tao T, Sun J, Wang Y, Gao N, Kamm KE, Stull JT, Zhu MS*: In vivo roles for myosin phosphatase targeting subunit-1 phosphorylation sites T694 and T852 in bladder smooth muscle contraction. J Physiol 2015, 593(3):681-700.

19. Wang Y, Zhao W, Zhang L, Zhao YN, Li F, Zhang Z, Dai YD, Li WF, Qiao YN, Chen CP, Gao JM, Zhu MS*: Molecular and cellular basis of the regulation of lymphatic contractility and lymphatic absorption. The international journal of biochemistry & cell biology 2014, 53:134-140.

20. Qiao YN, He WQ, Chen CP, Zhang CH, Zhao W, Wang P, Zhang L, Wu YZ, Yang X, Peng YJ, Gao JM, Kamm KE, Stull JT, Zhu MS*: Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure. J Biol Chem 2014, 289(32):22512-22523.

21. Chen C, Tao T, Wen C, He WQ, Qiao YN, Gao YQ, Chen X, Wang P, Chen CP, Zhao W, Chen HQ, Ye AP, Peng YJ, Zhu MS*: Myosin light chain kinase (MLCK) regulates cell migration in a myosin regulatory light chain phosphorylation-independent mechanism. J Biol Chem 2014, 289(41):28478-28488.

22. He WQ^#, Qiao YN^#(Co-first), Peng YJ, Zha JM, Zhang CH, Chen C, Chen CP, Wang P, Yang X, Li CJ, Kamm KE, Stull JT, Zhu MS*: Altered contractile phenotypes of intestinal smooth muscle in mice deficient in myosin phosphatase target subunit 1. Gastroenterology 2013, 144(7):1456-1465, 1465.e1451-1455.

23. He WQ^#, Qiao YN^#(Co-first), Zhang CH, Peng YJ, Chen C, Wang P, Gao YQ, Chen C, Chen X, Tao T, Su XH, Li CJ, Kamm KE, Stull JT, Zhu MS*: Role of myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension. Am J Physiol Heart Circ Physiol 2011, 301(2):H584-591.

24. Zhang WC, Peng YJ, Zhang GS, He WQ, Qiao YN, Dong YY, Gao YQ, Chen C, Zhang CH, Li W, Shen HH, Ning W, Kamm KE, Stull JT, Gao X, Zhu MS*: Myosin light chain kinase is necessary for tonic airway smooth muscle contraction. J Biol Chem 2010, 285(8):5522-5531.

25. Peng YJ, He WQ, Tang J, Tao T, Chen C, Gao YQ, Zhang WC, He XY, Dai YY, Zhu NC, Lv N, Zhang CH, Qiao YN, Zhao LP, Gao X, Zhu MS*: Trio is a key guanine nucleotide exchange factor coordinating regulation of the migration and morphogenesis of granule cells in the developing cerebellum. J Biol Chem 2010, 285(32):24834-24844.